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The antibody against FCAR was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CD89. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against FCAR was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CD89. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of NIH-3T3 cells using CD89 Polyclonal Antibody
| Cat.No | ADC-36809A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FCAR |
| Target Synonyms | FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD antigen CD89 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human CD89. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P24071 |
Uniprot Id
P24071
Target Species
Human
Target Name
FCAR
Target Full Name
Immunoglobulin alpha Fc receptor
Target Function
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Target Subcellular Location
[Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.; [Isoform B-delta-S2]: Secreted.
Target Tissue Specificity
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however
Target Synonyms
FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD antigen CD89
Target Background
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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