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The antibody against FCGRT was raised in rabbit using the Recombinant Human IgG receptor FcRn large subunit p51 protein (24-297AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against FCGRT was raised in rabbit using the Recombinant Human IgG receptor FcRn large subunit p51 protein (24-297AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Western blotAll lanes: FCGRT antibody at 1:2000Lane 1: HepG2 whole cell lysateLane 2: Mouse liver tissueLane 3: A549 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 40 kDaObserved band size: 40 kDa
Western blotAll lanes: FCGRT antibody at 1:1000Lane 1: Mouse liver tissueLane 2: Mouse kidney tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 40 kDaObserved band size: 40 kDa2
Immunohistochemistry of paraffin-embedded human placenta tissue using FCGRT Antibody at dilution of 1:1003
| Cat.No | ADC-50518A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FCGRT |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human IgG receptor FcRn large subunit p51 protein (24-297AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P55899 |
Uniprot Id
P55899
Target Species
Human
Target Name
FCGRT
Target Full Name
IgG receptor FcRn large subunit p51
Target Function
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.; (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Target Protein Families
Immunoglobulin superfamily
Target Tissue Specificity
Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Target Research Area
Immunology
Target Synonyms
Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_HUMAN; FCGRT; FcRn alpha chain; FcRn; FCRN; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor
Target Background
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
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