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The antibody against FCHO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FCHO2 (NP_620137.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FCHO2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FCHO2 (NP_620137.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10154A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FCHO2 |
| Target Synonyms | FCHO2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FCHO2 (NP_620137.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q0JRZ9 | Immunogen Sequence |
Uniprot Id
Q0JRZ9
Target Species
Human
Target Name
FCHO2
Target Full Name
F-BAR domain only protein 2
Target Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Target Subcellular Location
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
FCHO family
Target Synonyms
FCHO2F-BAR domain only protein 2
Target Background
Enables identical protein binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle.
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