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The antibody against FDXR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 252-491 of human FDXR (NP_077728.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FDXR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 252-491 of human FDXR (NP_077728.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04046A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FDXR |
| Target Synonyms | ADR; ADXR; ANOA; FDXR | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, HepG2, Mouse ovary, Mouse testis, NCI-H460, Rat kidney, Rat lung | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 252-491 of human FDXR (NP_077728.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P22570 | Immunogen Sequence |
Uniprot Id
P22570
Target Species
Human
Target Name
FDXR
Target Full Name
NADPH:adrenodoxin oxidoreductase, mitochondrial
Target Function
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein.
Target Protein Families
Ferredoxin--NADP reductase type 1 family
Target Research Area
Cell Biology
Target Synonyms
Adrenodoxin reductase; ADRO_HUMAN; ADXR; AR; FDXR; Ferredoxin NADP(+) reductase; Ferredoxin reductase; Ferredoxin--NADP(+) reductase; mitochondrial; NADPH adrenodoxin oxidoreductase mitochondrial; NADPH:adrenodoxin oxidoreductase
Target Background
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene.
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