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The antibody against FEM1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FEM1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04621A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FEM1A |
| Target Synonyms | EPRAP; FEM1A | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 293T, K-562 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BSK4 | Immunogen Sequence |
Uniprot Id
Q9BSK4
Target Species
Human
Target Name
FEM1A
Target Full Name
Protein fem-1 homolog A
Target Function
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.
Target Subcellular Location
Mitochondrion. Cytoplasm.
Target Protein Families
Fem-1 family
Target Tissue Specificity
Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
Target Synonyms
AW611390; DKFZp762M136; EPRAP; Fem-1 homolog a (C. elegans); Fem1 homolog a; FEM1-alpha; FEM1-alpha-A; FEM1a; FEM1a-A; FEM1A_HUMAN; Fem1aa; Feminization 1 homolog a (C. elegans); Feminization 1 homolog a; MGC114562; MGC117925; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; Protein fem-1 homolog A-A
Target Background
Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion.
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