Rabbit anti-Human FEM1A Polyclonal Antibody

Uniprot Id

Q9BSK4

Target Species

Human

Target Name

FEM1A

Target Full Name

Protein fem-1 homolog A

Target Function

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling.

Target Subcellular Location

Mitochondrion. Cytoplasm.

Target Protein Families

Fem-1 family

Target Tissue Specificity

Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).

Target Synonyms

AW611390; DKFZp762M136; EPRAP; Fem-1 homolog a (C. elegans); Fem1 homolog a; FEM1-alpha; FEM1-alpha-A; FEM1a; FEM1a-A; FEM1A_HUMAN; Fem1aa; Feminization 1 homolog a (C. elegans); Feminization 1 homolog a; MGC114562; MGC117925; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; Protein fem-1 homolog A-A

Target Background

Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion.