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The antibody against FGD5 was raised in rabbit using the Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (1203-1462AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against FGD5 was raised in rabbit using the Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (1203-1462AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human gastric cancer using FGD5 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human bladder cancer using FGD5 Antibody at dilution of 1:1002
| Cat.No | ADC-17033A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FGD5 |
| Target Synonyms | FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (1203-1462AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6ZNL6 |
Uniprot Id
Q6ZNL6
Target Species
Human
Target Name
FGD5
Target Full Name
FYVE, RhoGEF and PH domain-containing protein 5
Target Function
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Target Tissue Specificity
Expressed in endothelial cells (at protein level).
Target Synonyms
FGD5; ZFYVE23FYVE; RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23
Target Background
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Located in plasma membrane.
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