Rabbit anti-Human FHL1 Polyclonal Antibody

Uniprot Id

Q13642

Target Species

Human

Target Name

FHL1

Target Full Name

Four and a half LIM domains protein 1

Target Function

May have an involvement in muscle development or hypertrophy.

Target Involvement

Emery-Dreifuss muscular dystrophy 6, X-linked (EDMD6); Scapuloperoneal myopathy, X-linked dominant (SPM); Myopathy, X-linked, with postural muscle atrophy (XMPMA); Reducing body myopathy, X-linked 1A, severe, with infantile or early childhood onset (RBMX1A); Reducing body myopathy, X-linked 1B, with late childhood or adult onset (RBMX1B)

Target Subcellular Location

[Isoform 1]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes.

Target Tissue Specificity

Isoform 1 is highly expressed in skeletal muscle and to a lesser extent in heart, placenta, ovary, prostate, testis, small intestine, colon and spleen. Expression is barely detectable in brain, lung, liver, kidney, pancreas, thymus and peripheral blood le

Target Research Area

Immunology

Target Synonyms

bA535K18.1; FHL 1; FHL 1B; FHL-1; FHL1; FHL1 protein; FHL1_HUMAN; FHL1A; FHL1B; FLH1A; Four and a half LIM domains 1; Four and a half LIM domains protein 1; Four and a half Lin11 Isl 1 and Mec 3 domains 1; four-and-a-half Lin11; Isl-1 and Mec-3; KYO T; KYOT; mouse; homolog of; LIM protein SLIMMER; MGC111107; RAM14-1; RBMX1A; RBMX1B; RBP associated molecule 14-1; RP11-535K18.1; Skeletal muscle LIM protein 1; Skeletal muscle LIM-protein 1; SLIM 1; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA

Target Background

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.