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The antibody against FIBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human FIBP (NP_004205.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against FIBP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human FIBP (NP_004205.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-06173A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FIBP |
| Target Synonyms | FGFIBP; FIBP-1; TROFAS; FIBP | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3, Mouse skeletal muscle | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human FIBP (NP_004205.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43427 | Immunogen Sequence |
Uniprot Id
O43427
Target Species
Human
Target Name
FIBP
Target Full Name
Acidic fibroblast growth factor intracellular-binding protein
Target Function
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo.
Target Involvement
Thauvin-Robinet-Faivre syndrome (TROFAS)
Target Subcellular Location
Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.
Target Tissue Specificity
Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.
Target Research Area
Signal Transduction
Target Synonyms
Acidic fibroblast growth factor intracellular-binding protein; aFGF intracellular-binding protein; FGF-1 intracellular-binding protein; FGFIBP; FIBP; FIBP-1; FIBP_HUMAN; FIBP1; fibroblast growth factor (acidic) intracellular binding protein; OTTHUMP00000234231; OTTHUMP00000234232; OTTHUMP00000234233
Target Background
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.
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