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The antibody against FIBP was raised in rabbit using the Recombinant Human Acidic fibroblast growth factor intracellular-binding protein (2-357AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against FIBP was raised in rabbit using the Recombinant Human Acidic fibroblast growth factor intracellular-binding protein (2-357AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using FIBP Antibody at dilution of 1:1002
| Cat.No | ADC-44100A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FIBP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Acidic fibroblast growth factor intracellular-binding protein (2-357AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43427 |
Uniprot Id
O43427
Target Species
Human
Target Name
FIBP
Target Full Name
Acidic fibroblast growth factor intracellular-binding protein
Target Function
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo.
Target Involvement
Thauvin-Robinet-Faivre syndrome (TROFAS)
Target Subcellular Location
Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.
Target Tissue Specificity
Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.
Target Research Area
Signal Transduction
Target Synonyms
Acidic fibroblast growth factor intracellular-binding protein; aFGF intracellular-binding protein; FGF-1 intracellular-binding protein; FGFIBP; FIBP; FIBP-1; FIBP_HUMAN; FIBP1; fibroblast growth factor (acidic) intracellular binding protein; OTTHUMP00000234231; OTTHUMP00000234232; OTTHUMP00000234233
Target Background
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.
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