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The antibody against FLRT3 was raised in rabbit using the Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 protein (209-264AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against FLRT3 was raised in rabbit using the Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 protein (209-264AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-14953A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FLRT3 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Leucine-rich repeat transmembrane protein FLRT3 protein (209-264AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NZU0 |
Uniprot Id
Q9NZU0
Target Species
Human
Target Name
FLRT3
Target Full Name
Leucine-rich repeat transmembrane protein FLRT3
Target Function
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina. Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members. Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development.
Target Involvement
Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
Target Subcellular Location
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted. Cell projection, axon. Cell projection, growth cone membrane.
Target Tissue Specificity
Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.
Target Synonyms
fibronectin leucine rich transmembrane protein 3; Fibronectin-like domain-containing leucine-rich transmembrane protein 3; FLRT 3; FLRT3; FLRT3_HUMAN; KIAA1469; Leucine-rich repeat transmembrane protein FLRT3
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