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The antibody against FMN2 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Formin 2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against FMN2 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Formin 2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-34444A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FMN2 |
| Target Synonyms | FMN 2 antibody; Fmn2 antibody; FMN2_HUMAN antibody; Formin 2 antibody; Formin-2 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human Formin 2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NZ56 |
Uniprot Id
Q9NZ56
Target Species
Human
Target Name
FMN2
Target Full Name
Formin-2
Target Function
Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation.
Target Involvement
Mental retardation, autosomal recessive 47 (MRT47)
Target Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Nucleus. Nucleus, nucleolus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex.
Target Protein Families
Formin homology family, Cappuccino subfamily
Target Tissue Specificity
Expressed almost exclusively in the developing and mature central nervous system.
Target Research Area
Cell Biology
Target Synonyms
FMN 2; Fmn2; FMN2_HUMAN; Formin 2; Formin-2
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