Rabbit anti-Human FMN2 Polyclonal Antibody

Uniprot Id

Q9NZ56

Target Species

Human

Target Name

FMN2

Target Full Name

Formin-2

Target Function

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation.

Target Involvement

Mental retardation, autosomal recessive 47 (MRT47)

Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Nucleus. Nucleus, nucleolus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex.

Target Protein Families

Formin homology family, Cappuccino subfamily

Target Tissue Specificity

Expressed almost exclusively in the developing and mature central nervous system.

Target Research Area

Cell Biology

Target Synonyms

FMN 2; Fmn2; FMN2_HUMAN; Formin 2; Formin-2