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The antibody against FMOD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-376 of human FMOD (NP_002014.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FMOD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-376 of human FMOD (NP_002014.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11110A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FMOD |
| Target Synonyms | FM; SLRR2E; FMOD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BT-474, Mouse spleen, Rat skeletal muscle, Rat spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 19-376 of human FMOD (NP_002014.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q06828 | Immunogen Sequence |
Uniprot Id
Q06828
Target Species
Human
Target Name
FMOD
Target Full Name
Fibromodulin
Target Function
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
Target Synonyms
FM; SLRR2E; FMOD
Target Background
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants.
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