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The antibody against FN3K was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human FN3K (NP_071441.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FN3K was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human FN3K (NP_071441.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06082A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FN3K |
| Target Synonyms | FN3K | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human FN3K (NP_071441.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKI | Uniprot ID | Q9H479 |
Uniprot Id
Q9H479
Target Species
Human
Target Name
FN3K
Target Full Name
Fructosamine-3-kinase
Target Function
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines.
Target Protein Families
Fructosamine kinase family
Target Tissue Specificity
Widely expressed. Expressed in erythrocytes.
Target Synonyms
FN3KFructosamine-3-kinase; EC 2.7.1.171; Protein-psicosamine 3-kinase FN3K; Protein-ribulosamine 3-kinase FN3K; EC 2.7.1.172
Target Background
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation.
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