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The antibody against FNDC4 was raised in rabbit using the Recombinant Human Fibronectin type III domain-containing protein 4 protein (45-167AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against FNDC4 was raised in rabbit using the Recombinant Human Fibronectin type III domain-containing protein 4 protein (45-167AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-18202A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FNDC4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Fibronectin type III domain-containing protein 4 protein (45-167AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H6D8 |
Uniprot Id
Q9H6D8
Target Species
Human
Target Name
FNDC4
Target Full Name
Fibronectin type III domain-containing protein 4
Target Function
Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Secreted.
Target Tissue Specificity
Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).
Target Synonyms
Fibronectin type III domain containing 4; Fibronectin type III domain containing protein 4; Fibronectin type III domain-containing protein 4; Fibronectin type III repeat containing protein 1; Fibronectin type III repeat-containing protein 1; FLJ22362; FNDC 4; FNDC4; FNDC4_HUMAN; FRCP 1; FRCP1
Target Background
Involved in response to transforming growth factor beta. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to be active in extracellular region and plasma membrane.
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