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The antibody against FRZB was raised in rabbit using the Recombinant Human Secreted frizzled-related protein 3 protein (166-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against FRZB was raised in rabbit using the Recombinant Human Secreted frizzled-related protein 3 protein (166-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using FRZB Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using FRZB Antibody at dilution of 1:1002
| Cat.No | ADC-17452A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FRZB |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Secreted frizzled-related protein 3 protein (166-325AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q92765 |
Uniprot Id
Q92765
Target Species
Human
Target Name
FRZB
Target Full Name
Secreted frizzled-related protein 3
Target Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Target Involvement
Osteoarthritis 1 (OS1)
Target Subcellular Location
Secreted.
Target Protein Families
Secreted frizzled-related protein (sFRP) family
Target Tissue Specificity
Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot
Target Synonyms
FRZB; FIZ; FRE; FRP; FRZB1; SFRP3; Secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1
Target Background
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
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