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The antibody against GAD1 was raised in rabbit using the Peptide sequence around aa.17~21(A-D-P-N-T) derived from Human GAD67(GAD1). as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
The antibody against GAD1 was raised in rabbit using the Peptide sequence around aa.17~21(A-D-P-N-T) derived from Human GAD67(GAD1). as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extract from Rat brain and Mouse brain Tissue using GAD67(GAD1) Antibody
| Cat.No | ADC-43162A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAD1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around aa.17~21(A-D-P-N-T) derived from Human GAD67(GAD1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99259 |
Uniprot Id
Q99259
Target Species
Human
Target Name
GAD1
Target Full Name
Glutamate decarboxylase 1
Target Function
Catalyzes the production of GABA.
Target Involvement
Cerebral palsy, spastic quadriplegic 1 (CPSQ1)
Target Protein Families
Group II decarboxylase family
Target Tissue Specificity
Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain.
Target Synonyms
67 kDa glutamic acid decarboxylase; CPSQ1; DCE1; DCE1_HUMAN; EC 4.1.1.15; FLJ45882; GAD 1; GAD 67; GAD; GAD-67; GAD1; Glutamate decarboxylase 1 (brain; 67kDa); Glutamate decarboxylase 1; Glutamate decarboxylase 1 brain 67kD; Glutamate decarboxylase 1 brain 67kDa; Glutamate decarboxylase 67 kDa isoform; Glutamate decarboxylase; brain; 67-KD; OTTHUMP00000041054; OTTHUMP00000041055; OTTHUMP00000228572; SCP
Target Background
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
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