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The antibody against GAD2 was raised in rabbit using the Peptide sequence around aa.148~152 (E-L-A-D-Q) derived from Human GAD65 (GAD2). as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
The antibody against GAD2 was raised in rabbit using the Peptide sequence around aa.148~152 (E-L-A-D-Q) derived from Human GAD65 (GAD2). as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extract from Rat brain, Mouse brain tissue and Hela, 3T3 cells using GAD65(GAD2)) Antibody
| Cat.No | ADC-43177A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAD2 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around aa.148~152 (E-L-A-D-Q) derived from Human GAD65 (GAD2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q05329 |
Uniprot Id
Q05329
Target Species
Human
Target Name
GAD2
Target Full Name
Glutamate decarboxylase 2
Target Function
Catalyzes the production of GABA.
Target Subcellular Location
Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Target Protein Families
Group II decarboxylase family
Target Synonyms
GAD65; GAD65/GAD2
Target Background
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
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