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The antibody against GALNS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 353-522 of human GALNS (NP_000503.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against GALNS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 353-522 of human GALNS (NP_000503.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03777A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GALNS |
| Target Synonyms | GAS; MPS4A; GalN6S; GALNAC6S; GALNS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 293T, HT-29, MCF7, Mouse brain, Mouse intestine | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 353-522 of human GALNS (NP_000503.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | AGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH | Uniprot ID | P34059 |
Uniprot Id
P34059
Target Species
Human
Target Name
GALNS
Target Full Name
N-acetylgalactosamine-6-sulfatase
Target Involvement
Mucopolysaccharidosis 4A (MPS4A)
Target Subcellular Location
Lysosome.
Target Protein Families
Sulfatase family
Target Research Area
Signal Transduction
Target Synonyms
GALNSN-acetylgalactosamine-6-sulfatase; EC 3.1.6.4; Chondroitinsulfatase; Chondroitinase; Galactose-6-sulfate sulfatase; GalN6S; N-acetylgalactosamine-6-sulfate sulfatase; GalNAc6S sulfatase
Target Background
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.
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