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The antibody against GAMT was raised in rabbit using the Human GAMT as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against GAMT was raised in rabbit using the Human GAMT as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-48493A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAMT |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Human GAMT | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14353 |
Uniprot Id
Q14353
Target Species
Human
Target Name
GAMT
Target Full Name
Guanidinoacetate N-methyltransferase
Target Function
Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.
Target Involvement
Cerebral creatine deficiency syndrome 2 (CCDS2)
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, RMT2 methyltransferase family
Target Tissue Specificity
Expressed in liver.
Target Synonyms
CCDS2; Epididymis secretory protein Li 20; GAMT; GAMT_HUMAN; Guanidinoacetate N methyltransferase; Guanidinoacetate N-methyltransferase; HEL-S-20; PIG2; TP53I2
Target Background
The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13.
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