Rabbit anti-Human GBP1 Monoclonal Antibody

The antibody against GBP1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 493-592 of human GBP1 (P32455) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-14460A

Number

Cat.No	ADA-14460A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	GBP1
Target Synonyms	GBP1; guanylate-binding protein 1	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Rat heart, Jurkat	Application	ELISA, WB, IHC-P

Cat.No

ADA-14460A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

GBP1

Target Synonyms

GBP1; guanylate-binding protein 1

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Rat heart, Jurkat

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 493-592 of human GBP1 (P32455).	Target Species	Human
Immunogen Sequence	RVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS	Uniprot ID	P32455

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 493-592 of human GBP1 (P32455).

Target Species

Human

Immunogen Sequence

RVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS

Uniprot ID

P32455

Background Information

Uniprot Id

P32455
Target Species

Human
Target Name

GBP1
Target Full Name

Guanylate-binding protein 1
Target Function

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Target Subcellular Location

Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
Target Protein Families

TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
Target Synonyms

GBP 1; GBP-1; GBP1; GBP1_HUMAN; GTP binding protein 1; GTP-binding protein 1; Guanine nucleotide binding protein 1; Guanine nucleotide-binding protein 1; Guanylate binding protein 1; Guanylate binding protein 1 interferon inducible 67kDa; Guanylate binding protein 1 interferon inducible; HuGBP 1; HuGBP-1; HuGBP1; Interferon induced guanylate binding protein 1; Interferon-induced guanylate-binding protein 1; OTTHUMP00000012352
Target Background

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.

Rabbit anti-Human GBP1 Monoclonal Antibody

Specifications

Immunogen Information

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