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The antibody against GCA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against GCA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02691A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GCA |
| Target Synonyms | GCL; GCA | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, HL-60, HT-29 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P28676 | Immunogen Sequence |
Uniprot Id
P28676
Target Species
Human
Target Name
GCA
Target Full Name
Grancalcin
Target Function
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
Target Subcellular Location
Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side.
Target Tissue Specificity
Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.
Target Research Area
others
Target Synonyms
GCA; GCL; Grancalcin
Target Background
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants.
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