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Rabbit anti-Human GCLM Monoclonal Antibody

The antibody against GCLM was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 175-274 of human GCLM (P48507) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16556A

The antibody against GCLM was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 175-274 of human GCLM (P48507) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-16556A ClonalityMonoclonal
Host SpeciesRabbitTarget NameGCLM
Target SynonymsGLCLR; GCLMFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, A-431, U-2OSApplicationELISA, WB

Immunogen Information


Immunogen DescriptionA synthetic peptide corresponding to a sequence within amino acids 175-274 of human GCLM (P48507).Target SpeciesHuman
Immunogen SequenceLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGSUniprot IDP48507
Background Information
  • Uniprot Id

    P48507

  • Target Species

    Human

  • Target Name

    GCLM

  • Target Full Name

    Glutamate--cysteine ligase regulatory subunit

  • Target Synonyms

    Gamma ECS regulatory subunit; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; GCLM; GCS light chain; GLCLR; Glutamate cysteine ligase regulatory subunit; Glutamate--cysteine ligase modifier subunit; Glutamate--cysteine ligase regulatory subunit; GSC light chain; GSH0_HUMAN

  • Target Background

    Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

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