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The antibody against GCLM was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GCLM was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11931A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GCLM |
| Target Synonyms | GLCLR; GCLM | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 22Rv1, ES2, H460, HT-29, K562, Mouse liver, U-251MG, U-937 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P48507 | Immunogen Sequence |
Uniprot Id
P48507
Target Species
Human
Target Name
GCLM
Target Full Name
Glutamate--cysteine ligase regulatory subunit
Target Synonyms
Gamma ECS regulatory subunit; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; GCLM; GCS light chain; GLCLR; Glutamate cysteine ligase regulatory subunit; Glutamate--cysteine ligase modifier subunit; Glutamate--cysteine ligase regulatory subunit; GSC light chain; GSH0_HUMAN
Target Background
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
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