Rabbit anti-Human GCN1L1 Polyclonal Antibody

Uniprot Id

Q92616

Target Species

Human

Target Name

GCN1

Target Full Name

Stalled ribosome sensor GCN1

Target Function

Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion

Target Subcellular Location

Cytoplasm.

Target Protein Families

GCN1 family

Target Tissue Specificity

Ubiquitously expressed. Expressed in skeletal muscules, ovary and testis.

Target Synonyms

eIF-2-alpha kinase activator GCN1; GCN1 (general control of amino acid synthesis yeast homolog) like ; GCN1 (general control of amino acid synthesis 1 yeast) like 1; GCN1; GCN1 eIF-2-alpha kinase activator homolog; GCN1 general control of amino acid synthesis 1 like 1 ; GCN1 general control of amino acid synthesis 1 like 1 (yeast); GCN1 like protein 1; GCN1-like protein 1; GCN1_HUMAN; GCN1L; General control of amino-acid synthesis 1-like protein 1; HsGCN1; Translational activator gcn1