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The antibody against GDAP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against GDAP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-02934A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GDAP1 |
| Target Synonyms | CMT4; CMT4A; CMTRIA; GDAP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, HepG2, MCF7, Mouse brain, Mouse spinal cord | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8TB36 | Immunogen Sequence |
Uniprot Id
Q8TB36
Target Species
Human
Target Name
GDAP1
Target Full Name
Ganglioside-induced differentiation-associated protein 1
Target Function
Regulates the mitochondrial network by promoting mitochondrial fission.
Target Involvement
Charcot-Marie-Tooth disease 4A (CMT4A); Charcot-Marie-Tooth disease, axonal, with vocal cord paresis, autosomal recessive (CMT2RV); Charcot-Marie-Tooth disease 2K (CMT2K); Charcot-Marie-Tooth disease, recessive, intermediate type, A (CMTRIA)
Target Subcellular Location
Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm.
Target Protein Families
GST superfamily
Target Tissue Specificity
Highly expressed in whole brain and spinal cord. Predominant expression in central tissues of the nervous system not only in neurons but also in Schwann cells.
Target Synonyms
GDAP1; Ganglioside-induced differentiation-associated protein 1; GDAP1
Target Background
This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene.
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