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The antibody against GID8 was raised in rabbit using the Recombinant Human Glucose-induced degradation protein 8 homolog protein (1-228AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against GID8 was raised in rabbit using the Recombinant Human Glucose-induced degradation protein 8 homolog protein (1-228AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using GID8 Antibody at dilution of 1:100
| Cat.No | ADC-18015A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GID8 |
| Target Synonyms | GID8 antibody; C20orf11 antibody; TWA1Glucose-induced degradation protein 8 homolog antibody; Two hybrid-associated protein 1 with RanBPM antibody; Twa1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Glucose-induced degradation protein 8 homolog protein (1-228AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NWU2 |
Uniprot Id
Q9NWU2
Target Species
Human
Target Name
GID8
Target Full Name
Glucose-induced degradation protein 8 homolog
Target Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
GID8 family
Target Tissue Specificity
Up-regulated in colorectal cancer tissues (at protein level).
Target Synonyms
GID8; C20orf11; TWA1Glucose-induced degradation protein 8 homolog; Two hybrid-associated protein 1 with RanBPM; Twa1
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