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The antibody against GINS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 108-207 of human GINS4 (NP_115712.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GINS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 108-207 of human GINS4 (NP_115712.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-08954A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GINS4 |
| Target Synonyms | SLD5; GINS4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, MCF7, Mouse thymus, Rat fat, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 108-207 of human GINS4 (NP_115712.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | LEKEKTRPEGEPSSLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQENILVEPDTDEQRDYVIDLEKGSQHLIR | Uniprot ID | Q9BRT9 |
Uniprot Id
Q9BRT9
Target Species
Human
Target Name
GINS4
Target Full Name
DNA replication complex GINS protein SLD5
Target Function
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
Target Subcellular Location
Nucleus. Chromosome. Cytoplasm.
Target Protein Families
GINS4/SLD5 family
Target Synonyms
DNA replication complex GINS protein SLD5; GINS complex subunit 4 (Sld5 homolog); GINS complex subunit 4; GINS4; SLD5; SLD5 homolog; SLD5 S cerevisiae homolog of; SLD5_HUMAN
Target Background
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.
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