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The antibody against GJA8 was raised in rabbit using the Recombinant Human Gap junction alpha-8 protein (286-432AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against GJA8 was raised in rabbit using the Recombinant Human Gap junction alpha-8 protein (286-432AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human liver cancer using GJA8 Antibody at dilution of 1:1002
| Cat.No | ADC-12712A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GJA8 |
| Target Synonyms | GJA8; Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Gap junction alpha-8 protein (286-432AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P48165 |
Uniprot Id
P48165
Target Species
Human
Target Name
GJA8
Target Full Name
Gap junction alpha-8 protein
Target Function
Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Target Involvement
Cataract 1, multiple types (CTRCT1)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Target Protein Families
Connexin family, Alpha-type (group II) subfamily
Target Tissue Specificity
Eye lens.
Target Synonyms
GJA8; Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70
Target Background
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
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