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The antibody against GK was raised in rabbit using the Fusion protein corresponding to a region derived from internal residues of Human glycerol kinase as the immunogen. This antibody exists as a polyclonal antibody to the immunogen, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GK was raised in rabbit using the Fusion protein corresponding to a region derived from internal residues of Human glycerol kinase as the immunogen. This antibody exists as a polyclonal antibody to the immunogen, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/60.
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/60.2
| Cat.No | ADC-40643A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GK |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | 0.05% NaN3, 50% Glycerol, Rabbit IgG in pH7.3 PBS | Purification Method | Antigen affinity purified |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Fusion protein corresponding to a region derived from internal residues of Human glycerol kinase | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P32189 |
Uniprot Id
P32189
Target Species
Human
Target Name
GK
Target Full Name
Glycerol kinase
Target Function
Key enzyme in the regulation of glycerol uptake and metabolism.
Target Involvement
Glycerol kinase deficiency (GKD)
Target Subcellular Location
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
Target Protein Families
FGGY kinase family
Target Tissue Specificity
Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.
Target Synonyms
ATP glycerol 3 phosphotransferase; ATP:glycerol 3 phosphotransferase; ATP:glycerol 3-phosphotransferase; D930012N15Rik; GK; GK1; GKD; GLPK_HUMAN; Glycerokinase; Glycerol kinase; OTTHUMP00000023108; OTTHUMP00000023109; OTTHUMP00000215321
Target Background
The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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