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Rabbit anti-Human GLA Polyclonal Antibody, Biotin conjugated

The antibody against GLA was raised in rabbit using the Recombinant Human Alpha-galactosidase A protein (32-429AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-50766A

The antibody against GLA was raised in rabbit using the Recombinant Human Alpha-galactosidase A protein (32-429AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-50766A ClonalityPolyclonal
Host SpeciesRabbitTarget NameGLA
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateBiotin conjugated
ApplicationELISAStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human Alpha-galactosidase A protein (32-429AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP06280
Background Information
  • Uniprot Id

    P06280

  • Target Species

    Human

  • Target Name

    GLA

  • Target Full Name

    Alpha-galactosidase A

  • Target Function

    Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.

  • Target Involvement

    Fabry disease (FD)

  • Target Subcellular Location

    Lysosome.

  • Target Protein Families

    Glycosyl hydrolase 27 family

  • Target Research Area

    Cardiovascular

  • Target Synonyms

    AGAL_HUMAN; Agalsidase alfa; Alpha D galactosidase A; Alpha D galactoside galactohydrolase 1; Alpha D galactoside galactohydrolase; Alpha gal A; Alpha galactosidase A; Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; Alpha-galactosidase A; GALA; Galactosidase; alpha; GLA; GLA protein; Melibiase

  • Target Background

    This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

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