Rabbit anti-Human GLRA1 Polyclonal Antibody

Uniprot Id

P23415

Target Species

Human

Target Name

GLRA1

Target Full Name

Glycine receptor subunit alpha-1

Target Function

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.

Target Involvement

Hyperekplexia 1 (HKPX1)

Target Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Perikaryon. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Glycine receptor (TC 1.A.9.3) subfamily, GLRA1 sub-subfamily

Target Research Area

Others

Target Synonyms

GLRA1; GLRA1_HUMAN; Glycine receptor 48 kDa subunit; Glycine receptor alpha 1; Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; Glycine receptor; alpha 1 subunit; HKPX1; STHE

Target Background

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found.