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The antibody against Glycophorin C (GYPC) was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 49-128 of human Glycophorin C (GYPC) (P04921) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against Glycophorin C (GYPC) was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 49-128 of human Glycophorin C (GYPC) (P04921) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-13753A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Glycophorin C (GYPC) |
| Target Synonyms | GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2'; Glycophorin C (GYPC) | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | K-562, Mouse liver, Rat liver | Application | ELISA, WB, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 49-128 of human Glycophorin C (GYPC) (P04921). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | METSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI | Uniprot ID | P04921 |
Uniprot Id
P04921
Target Species
Human
Target Name
GYPC
Target Full Name
Glycophorin-C
Target Function
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Target Subcellular Location
Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
Target Protein Families
Glycophorin-C family
Target Tissue Specificity
Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
Target Synonyms
GYPC; GLPC; GPC; Glycophorin-C; Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD antigen CD236
Target Background
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants.
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