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The antibody against GMPS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 394-693 of human GMPS (NP_003866.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
The antibody against GMPS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 394-693 of human GMPS (NP_003866.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
| Cat.No | ADA-09457A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GMPS |
| Target Synonyms | GATD7; GMPS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, Rat heart, HL-60, MCF-7, Mouse brain, SKOV3, U-251MG | Application | ELISA, WB, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 394-693 of human GMPS (NP_003866.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P49915 | Immunogen Sequence |
Uniprot Id
P49915
Target Species
Human
Target Name
GMPS
Target Full Name
GMP synthase [glutamine-hydrolyzing]
Target Function
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
Target Involvement
A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
Target Subcellular Location
Cytoplasm.
Target Synonyms
GATD7; Glutamine amidotransferase; GMP synthase [glutamine hydrolyzing]; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Gmps; GUAA_HUMAN; Guanine monophosphate synthase; Guanine monphosphate synthetase; Guanosine 5' monophosphate synthase; MLL/GMPS fusion protein; Testicular tissue protein Li 82
Target Background
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
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