Rabbit anti-Human GNA12 Polyclonal Antibody

Uniprot Id

Q03113

Target Species

Human

Target Name

GNA12

Target Full Name

Guanine nucleotide-binding protein subunit alpha-12

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.

Target Subcellular Location

Cell membrane; Lipid-anchor. Lateral cell membrane; Lipid-anchor. Cytoplasm.

Target Protein Families

G-alpha family, G(12) subfamily

Target Synonyms

RMP; gep; NNX3; HG1M1; GNA12

Target Background

Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion.