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The antibody against GNL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GNL3 (NP_996562.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.
The antibody against GNL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GNL3 (NP_996562.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.
| Cat.No | ADA-09480A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNL3 |
| Target Synonyms | NS; E2IG3; NNP47; C77032; GNL3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T | Application | ELISA, WB, IF/ICC, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GNL3 (NP_996562.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BVP2 | Immunogen Sequence |
Uniprot Id
Q9BVP2
Target Species
Human
Target Name
GNL3
Target Full Name
Guanine nucleotide-binding protein-like 3
Target Function
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
Target Subcellular Location
Nucleus. Nucleus, nucleolus.
Target Protein Families
TRAFAC class YlqF/YawG GTPase family
Target Tissue Specificity
Increased levels in lung tissue in cancer patients.
Target Synonyms
C77032 ; E2 induced gene 3 protein; E2-induced gene 3 protein; E2IG3; Estradiol induced nucleotide binding protein; GNL3; GNL3_HUMAN; Guanine nucleotide binding protein like 3 (nucleolar); Guanine nucleotide binding protein like 3; Guanine nucleotide-binding protein-like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP binding protein 3 ; Nucleolar GTP-binding protein 3; Nucleostemin; Putative nucleotide binding protein estradiol induced
Target Background
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
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