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The antibody against GNS was raised in rabbit using the Recombinant Human N-acetylglucosamine-6-sulfatase protein (293-552AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GNS was raised in rabbit using the Recombinant Human N-acetylglucosamine-6-sulfatase protein (293-552AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using GNS Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using GNS Antibody at dilution of 1:1002
| Cat.No | ADC-16856A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNS |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human N-acetylglucosamine-6-sulfatase protein (293-552AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P15586 |
Uniprot Id
P15586
Target Species
Human
Target Name
GNS
Target Full Name
N-acetylglucosamine-6-sulfatase
Target Involvement
Mucopolysaccharidosis 3D (MPS3D)
Target Subcellular Location
Lysosome.
Target Protein Families
Sulfatase family
Target Synonyms
2610016K11Rik; AU042285; C87209; G6S; Glucosamine (N-acetyl) 6 sulfatase; Glucosamine 6 sulfatase; Glucosamine-6-sulfatase; GNS; GNS_HUMAN; MGC21274; N acetylglucosamine 6 sulfatase [Precursor]; N-acetylglucosamine-6-sulfatase; N28088
Target Background
The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
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