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The antibody against GOT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 244-413 of human GOT1 (NP_002070.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against GOT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 244-413 of human GOT1 (NP_002070.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-09642A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GOT1 |
| Target Synonyms | AST; AST1; SGOT; cCAT; GIG18; cAspAT; ASTQTL1; GOT1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Rat brain, HepG2, Mouse brain, Mouse liver, Rat liver | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 244-413 of human GOT1 (NP_002070.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | FVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ | Uniprot ID | P17174 |
Uniprot Id
P17174
Target Species
Human
Target Name
GOT1
Target Full Name
Aspartate aminotransferase, cytoplasmic
Target Function
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class-I pyridoxal-phosphate-dependent aminotransferase family
Target Synonyms
AST; AST1; SGOT; cCAT; GIG18; cAspAT; ASTQTL1; GOT1
Target Background
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
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