Rabbit anti-Human GOT1 Polyclonal Antibody

Uniprot Id

P17174

Target Species

Human

Target Name

GOT1

Target Full Name

Aspartate aminotransferase, cytoplasmic

Target Function

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class-I pyridoxal-phosphate-dependent aminotransferase family

Target Synonyms

AST; AST1; SGOT; cCAT; GIG18; cAspAT; ASTQTL1; GOT1

Target Background

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.