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The antibody against GP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 111-387 of human GP2 (NP_001007243.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 111-387 of human GP2 (NP_001007243.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06386A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Gp2 |
| Target Synonyms | ZAP75; GP2 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 111-387 of human GP2 (NP_001007243.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P55259 | Immunogen Sequence |
Uniprot Id
P55259
Target Species
Human
Target Name
GP2
Target Full Name
Pancreatic secretory granule membrane major glycoprotein GP2
Target Function
Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
Target Subcellular Location
Zymogen granule membrane; Lipid-anchor, GPI-anchor. Secreted. Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-anchor. Endosome.
Target Tissue Specificity
Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level).
Target Synonyms
DKFZp779K0533; Glycoprotein 2 (zymogen granule membrane); GP2; GP2_HUMAN; Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75
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