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The antibody against GPC6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 320-530 of human GPC6 (NP_005699.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against GPC6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 320-530 of human GPC6 (NP_005699.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11276A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GPC6 |
| Target Synonyms | OMIMD1; GPC6 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 320-530 of human GPC6 (NP_005699.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y625 | Immunogen Sequence |
Uniprot Id
Q9Y625
Target Species
Human
Target Name
GPC6
Target Full Name
Glypican-6
Target Function
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling.
Target Involvement
Omodysplasia 1 (OMOD1)
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Secreted glypican-6]: Secreted, extracellular space.
Target Protein Families
Glypican family
Target Tissue Specificity
Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood le
Target Research Area
Signal Transduction
Target Synonyms
GPC 6; Glypican 6 [Precursor]; Glypican proteoglycan 6; Gpc6; GPC6_HUMAN; MGC126288 ; OMIMD1; PRO705; Secreted glypican 6; Secreted glypican-6; UNQ369
Target Background
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1.
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