Rabbit anti-Human GPD1 Polyclonal Antibody

Uniprot Id

P21695

Target Species

Human

Target Name

GPD1

Target Full Name

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Target Function

Has glycerol-3-phosphate dehydrogenase activity.

Target Involvement

Hypertriglyceridemia, transient infantile (HTGTI)

Target Subcellular Location

Cytoplasm.

Target Protein Families

NAD-dependent glycerol-3-phosphate dehydrogenase family

Target Tissue Specificity

Expressed in liver (at protein level).

Target Research Area

Signal Transduction

Target Synonyms

AI747587; cytoplasmic; EC 1.1.1.8; FLJ26652; G3PD; Gdc-1; Gdc1; Gdp1; Glycerol 3 phosphate dehydrogenase 1; Glycerol 3 phosphate dehydrogenase cytosolic; Glycerol 3 phosphate dehydrogenase soluble; Glycerol-3-phosphate dehydrogenase [NAD+]; Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic; Glycerol-3-phosphate dehydrogenase 1 (soluble); Glycerol-3-phosphate dehydrogenase; Glycerol-3-phosphate dehydrogenase, soluble ; Glycerphosphate dehydrogenase; GPD-C; gpd1; Gpd1 protein; Gpd3; GPDA_HUMAN; Gpdc; GPDH; GPDH-C; Gpdhc; HTGTI; KIAA4010; MGC93453; MGPD; mKIAA4010

Target Background

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.