Rabbit anti-Human GPNMB Polyclonal Antibody

Uniprot Id

Q14956

Target Species

Human

Target Name

GPNMB

Target Full Name

Transmembrane glycoprotein NMB

Target Function

Could be a melanogenic enzyme.

Target Involvement

Glioblastoma multiforme patients that exhibit increased mRNA and protein levels (>3-fold over normal brain) in biopsy samples have a significantly higher risk of death (PubMed:16609006). In the context of cancer immunotherapy, including that of melanoma, has been proposed to be used as a cell surface protein antigen targeted by antibodies coupled to cytotoxic drugs (PubMed:16489096).

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein.

Target Protein Families

PMEL/NMB family

Target Tissue Specificity

Widely expressed, but very low expression, if any, in the brain. Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level). Expressed in peripheral blood, but not bone marrow mononucle

Target Research Area

Immunology

Target Synonyms

Glycoprotein (transmembrane) nmb; Glycoprotein nmb; Glycoprotein nmb like protein; Gpnmb; GPNMB_HUMAN; HGFIN; NMB; Osteoactivin; Transmembrane glycoprotein; Transmembrane glycoprotein HGFIN; Transmembrane glycoprotein NMB

Target Background

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.