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The antibody against ADGRG6 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human DREG. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IF, ELISA.
The antibody against ADGRG6 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human DREG. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IF, ELISA.
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Western Blot analysis of HepG2 cells using DREG Polyclonal Antibody
| Cat.No | ADC-38807A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADGRG6 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human DREG. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86SQ4 |
Uniprot Id
Q86SQ4
Target Species
Human
Target Name
ADGRG6
Target Full Name
Adhesion G-protein coupled receptor G6
Target Function
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.
Target Involvement
Lethal congenital contracture syndrome 9 (LCCS9)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
Target Tissue Specificity
Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
Target Research Area
Others
Target Synonyms
adhesion G protein coupled receptor G6; APG1; Developmentally regulated G protein coupled receptor; Developmentally regulated G-protein-coupled receptor; dj287g14.2; DREG; G protein coupled receptor 126; G-protein coupled receptor 126; GP126_HUMAN; GPR126; HBV PreS1 transactivated protein 2; HBV PreS1-transactivated protein 2; LCCS9; OTTHUMP00000017320; OTTHUMP00000237093; OTTHUMP00000237094; OTTHUMP00000237115; PR126; Probable G protein coupled receptor 126 [Precursor]; Probable G protein coupled receptor 126; Probable G-protein coupled receptor 126 [Precursor]; Probable G-protein coupled receptor 126; PS1TP2; Vascular inducible G protein coupled receptor; Vascular inducible G protein-coupled receptor; VIGR
Target Background
This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene.
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