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The antibody against GRB14 was raised in rabbit using the Fusion protein of Human GRB14 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against GRB14 was raised in rabbit using the Fusion protein of Human GRB14 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-31891A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GRB14 |
| Target Synonyms | GRB14Growth factor receptor-bound protein 14 antibody; GRB14 adapter protein antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Fusion protein of Human GRB14 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14449 |
Uniprot Id
Q14449
Target Species
Human
Target Name
GRB14
Target Full Name
Growth factor receptor-bound protein 14
Target Function
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Target Subcellular Location
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Target Protein Families
GRB7/10/14 family
Target Tissue Specificity
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Target Synonyms
GRB14Growth factor receptor-bound protein 14; GRB14 adapter protein
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