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The antibody against GREM2 was raised in rabbit using the Synthetic peptide from Human protein at AA range: 71-120 as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against GREM2 was raised in rabbit using the Synthetic peptide from Human protein at AA range: 71-120 as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western blot analysis of Mouse kidney, 293T, Mouse lung, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:2002
Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:2003
| Cat.No | ADC-12991A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GREM2 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol., PBS | Purification Method | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide from Human protein at AA range: 71-120 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H772 |
Uniprot Id
Q9H772
Target Species
Human
Target Name
GREM2
Target Full Name
Gremlin-2
Target Function
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
Target Involvement
Tooth agenesis, selective, 9 (STHAG9)
Target Subcellular Location
Secreted.
Target Protein Families
DAN family
Target Synonyms
BMP antagonist 2; CKTSF1B2; Cysteine knot superfamily 1; Cysteine knot superfamily 1 BMP antagonist 2; DAN domain family member 3; DAND 3; DAND3; GREM 2; Grem2; GREM2_HUMAN; Gremlin 2; Gremlin 2 cysteine knot superfamily homolog; Gremlin-2; Gremlin2; PRDC; Protein related to DAN and cerberus
Target Background
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
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