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The antibody against GSR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 273-522 of human GSR (NP_000628.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GSR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 273-522 of human GSR (NP_000628.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11757A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GSR |
| Target Synonyms | GR; GSRD; HEL-75; HEL-S-122m; GSR | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse kidney, A-549, Jurkat, LO2, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 273-522 of human GSR (NP_000628.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P00390 | Immunogen Sequence |
Uniprot Id
P00390
Target Species
Human
Target Name
GSR
Target Full Name
Glutathione reductase, mitochondrial
Target Function
Maintains high levels of reduced glutathione in the cytosol.
Target Subcellular Location
[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm.
Target Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Target Synonyms
GLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase; mitochondrial; GR; Gr1; GRase; GRD 1; GRD1; GSHR_HUMAN; GSR; MGC78522
Target Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
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