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The antibody against GSR was raised in rabbit using the Recombinant Human Glutathione reductase, mitochondrial protein (47-219AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against GSR was raised in rabbit using the Recombinant Human Glutathione reductase, mitochondrial protein (47-219AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human gastric cancer using GSR Antibody at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using GSR Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-13539A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GSR |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Glutathione reductase, mitochondrial protein (47-219AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P00390 |
Uniprot Id
P00390
Target Species
Human
Target Name
GSR
Target Full Name
Glutathione reductase, mitochondrial
Target Function
Maintains high levels of reduced glutathione in the cytosol.
Target Subcellular Location
[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm.
Target Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Target Synonyms
GLR1; GLUR; Glutathione reductase; Glutathione reductase mitochondrial; Glutathione reductase; mitochondrial; GR; Gr1; GRase; GRD 1; GRD1; GSHR_HUMAN; GSR; MGC78522
Target Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
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