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The antibody against GUK1 was raised in rabbit using the Synthetic peptide of Human GUK1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GUK1 was raised in rabbit using the Synthetic peptide of Human GUK1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26636A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GUK1 |
| Target Synonyms | ATP:GMP phosphotransferase antibody; FLJ42686 antibody; FLJ43710 antibody; GMK antibody; GMP kinase antibody; Guanylate kinase antibody; GUK1 antibody; KGUA_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human GUK1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q16774 |
Uniprot Id
Q16774
Target Species
Human
Target Name
GUK1
Target Full Name
Guanylate kinase
Target Function
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors. It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine.
Target Subcellular Location
Photoreceptor inner segment. Cytoplasm, cytosol.
Target Protein Families
Guanylate kinase family
Target Tissue Specificity
Widely expressed.
Target Research Area
Cancer
Target Synonyms
ATP:GMP phosphotransferase; FLJ42686; FLJ43710; GMK; GMP kinase; Guanylate kinase; GUK1; KGUA_HUMAN
Target Background
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
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